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Thymic serum factor (pig)

Nonathymulin

CAS: 63958-90-7

Molecular Formula: C33H54N12O15

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Thymic serum factor (pig) - Names and Identifiers

Name Nonathymulin
Synonyms Nonathymulin
Serum Thymic Factor
Thymic serum factor
Thymic serum factor (pig)
Serum thymic factor (porcine)
STF, SeruM ThyMic Factor, ThyMulin
PYR-ALA-LYS-SER-GLN-GLY-GLY-SER-ASN
pGlu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
Pyr-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn-OH trifluoroacetate salt
5-oxo-L-prolyl-L-alanyl-L-lysyl-L-seryl-L-glutaminylglycylglycyl-L-seryl-L-asparagine
L-Asparagine,5-oxo-L-prolyl-L-alanyl-L-lysyl-L-seryl-L-glutaminylglycylglycyl-L-seryl-
(sup 2)N-(N-(N-(N-(sup 2)N-(N-(sup 2)N-(N-(-5-Oxo-L-prolyl)-L-alanyl)-L-seryl)-L-glutaminyl)glycyl)glycyl)-L-seryl)-L-asparagine.
N(sup 2)-(N-(N-(N-(N(sup 2)-(N-(N(sup 2)-(N-(-5-Oxo-L-prolyl)-L-alanyl)-L-lysyl)-L-seryl)-L-glutaminyl)glycyl)glycyl)-L-seryl)-L-asparagine
CAS 63958-90-7
EINECS 236-855-3
InChI InChI=1/C33H54N12O15/c1-15(39-29(55)18-6-8-24(50)40-18)27(53)42-16(4-2-3-9-34)30(56)45-21(14-47)32(58)43-17(5-7-22(35)48)28(54)38-11-25(51)37-12-26(52)41-20(13-46)31(57)44-19(33(59)60)10-23(36)49/h15-21,46-47H,2-14,34H2,1H3,(H2,35,48)(H2,36,49)(H,37,51)(H,38,54)(H,39,55)(H,40,50)(H,41,52)(H,42,53)(H,43,58)(H,44,57)(H,45,56)(H,59,60)/t15-,16-,17-,18-,19-,20-,21-/m0/s1

Thymic serum factor (pig) - Physico-chemical Properties

Molecular FormulaC33H54N12O15
Molar Mass858.85
Density1.417±0.06 g/cm3(Predicted)
Boling Point1658.9±65.0 °C(Predicted)
Flash Point957.1°C
Solubility deionized water: soluble
Vapor Presure0mmHg at 25°C
AppearanceLyophilized powder
Colorwhite
pKa3.08±0.10(Predicted)
Storage Condition−20°C
Refractive Index1.575
MDLMFCD00076882
Physical and Chemical PropertiesThis product can regulate cellular immune function, anti-aging, anti-virus effect. It is stable to heat, and the biological activity does not decrease at 80 ℃. After being hydrolyzed into amino acids, the biological activity disappears. Raw material treatment the calf thymus was used as raw material to remove non-thymus tissue such as fat and fascia. After cold storage at -20 ° C., it was washed with sterile distilled water and minced in a sterilized meat grinder. According to the mass ratio of 1:1, the broken thymus and cold water for injection (China water hypotonic extraction, cold melt, can make the active polypeptide fully dissolved in water, improve the yield. Foreign reports, can also be extracted with physiological saline) mixed, placed in 10000r/min of high-speed tissue crushing crusher, mash 1 min to homogenate. Calf thymus [minced] → crushed thymus [cold water for injection] →[10000r/min, 1min] partial thermal denaturation of thymus homogenate, centrifugation, filtration the thymus homogenates were extracted by immersion below 10 °c and then frozen at -20 °c for 48h. After removal and thawing, the mixture was heated to 80 °c with stirring in a water bath for 5min, the temperature was rapidly decreased, and the mixture was refrigerated at -20 °c for 2-3 days. Take out the melt, at 2 deg C, 5000 r/min centrifugation for 40min, take the supernatant, Suction filtration under reduced pressure (filter pulp or 0.22 μm microporous membrane), get the clear extract of active polypeptide. Thymus homogenate [extraction below 10 ℃] →[-20 ℃, 48h] Frozen solution [80 ℃, 5min]→[5000r/min, 40min centrifugation] active polypeptide extract ultrafiltration, purification, subpackage and freeze-drying the clarified extract of the active polypeptide is subjected to ultrafiltration with an ultrafiltration membrane (with a relative molecular mass of less than 10,000 that can be retained) to obtain a refined solution, which is refrigerated at -20 °c. After passing the test, 3% mannitol (excipient) was added, sterile filtered, sub-packed, and freeze-dried to give Thymopolypeptides for Injection. Active polypeptide extract [ultrafiltration membrane] →[Mr<10000] refined liquid [freeze-drying] →[3% mannitol] Thymopolypeptides for Injection (note: the entire process of operation and equipment should be carried out in accordance with the provisions of the aseptic method of operation.)
UseThis product is for scientific research only and shall not be used for other purposes.

Thymic serum factor (pig) - Risk and Safety

WGK Germany3

Thymic serum factor (pig) - Introduction

Amino acid sequence: Glp-Ala-Lys-Ser-Gln-Gly-G?ly-Ser-Asn. Thymic non-peptide is often used to study the effects of this compound on gonadotropin-induced ovulation and pubertal mice.
Last Update：2022-10-16 17:27:39

Thymic serum factor (pig) - Reference Information

Application Serum thymic factor is an important factor to promote lymphocyte differentiation and enhance its function, which can stimulate the activity of immune cells, regulate immune function, enhance the body's non-specific cellular immunity and other effects.
uses is suitable for primary and secondary immunodeficiency diseases, diseases caused by immune dysfunction, adjuvant therapy of tumor, aplastic anemia, acute and chronic viral hepatitis, can also be used for lupus erythematosus, rheumatoid arthritis, allergic asthma.
Last Update：2024-04-09 15:16:52
Thymic serum factor (pig)
Supplier List
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Serum Thymic Factor Visit Supplier Webpage Request for quotation
CAS: 63958-90-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Cellmano Biotech Limited
Product Name: Thymalin, Thymulin Request for quotation
CAS: 63958-90-7
Tel: 008655165326643
Email: qilin@cellmano.com
Mobile: 008618156095617
QQ: 1761863581 Click to send a QQ messageSend QQ message
Shanghai Yuanye Bio-Technology Co., Ltd.
Product Name: Serum Thymic Factor Visit Supplier Webpage Request for quotation
CAS: 63958-90-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409 Click to send a QQ message
Wechat: 18301782025
Cellmano Biotech Limited
Product Name: Thymalin, Thymulin Request for quotation
CAS: 63958-90-7
Tel: 008655165326643
Email: qilin@cellmano.com
Mobile: 008618156095617
QQ: 1761863581 Click to send a QQ messageSend QQ message
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Thymic serum factor (pig)
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